Is the AnteBC (Breast) genetic test right for you?
AnteBC is a genetic test that assesses your risk of developing breast cancer. This test defines personal genetic predisposition for breast cancer. Based on personal risk level, it is possible to give scientific and practical personalised recommendations to prevent or detect breast cancer at an early stage when it is still treatable.
AnteBC test is recommended for UK women between the ages of 30-75.
This test is only suitable for individuals who have no previous history of breast cancer.
You can access this test:
- By purchasing it directly through Everything Genetic online (includes mandatory pre and post-test clinical support), or
- Through a private medical clinic or wellness services provider. Ask your clinician about how you can get this test.
This test includes mandatory pre and post-test clinical support by Everything Genetic.
Our price £249 (includes mandatory pre and post-test clinical support)
For Healthcare Providers and Employers:
Call us on +44 (0) 1270 623179 or email
partners@everythinggeneticltd.co.uk
You must be 18+ to order this test
- Why?►Close tab
Breast cancer is the most common cancer in women. Your individual breast cancer risk can be very high, whether or not there is a family history of cancer. Knowing your personal cancer risk is the key to cancer prevention and longevity. Based on the level of personal risk, the test provides medical and practical recommendations for preventing breast cancer and reducing its potential effects.
When determining genetic risk, it is possible to identify women at increased risk for breast cancer so that they can receive timely examinations and a personal follow-up plan. By implementing precision prevention, it is possible to reduce the incidence and impact of cancer and achieve a longer life.
- How?►Close tab
How to take the test?
It’s a simple ‘spit test’ that you can do in your own home – we don’t need a blood sample, all we need is your saliva. You’ll receive a kit in the post with clear instructions on giving your sample together with all the paperwork you need to sign, which you then post back to us.
- Process►Close tab
Direct from this website
Step 1: Buy the AnteBC (Breast) service
Click the ‘Buy now’ tab above and follow the instructions.
Step 2: Pre-test clinical support
Once you have ordered your test, you will be contacted by an Everything Genetic doctor and provided with clinical support on how the test can help you (this pre-test clinical support is mandatory). A test kit will then be sent directly to you.
Step 3: Provide a saliva sample
When you open your test kit, read the instructions carefully and use the enclosed tube to provide a saliva sample. Complete Test Request Form (A) (please sign consent for mandatory pre and post-test consultation), Informed Consent Form (B) and the Family History Questionnaire Form (C).
Step 4: Send your completed kit back to us
Post the sample pack at any post box using the postage-paid packing provided.
Step 5: Reporting
Your sample will be sequenced and your genes analysed. A report will be generated, usually within 4 weeks of receipt of your sample in the laboratory.
Step 6: Post-test clinical support
An Everything Genetic doctor will contact you to discuss your results and their implications for you (this post-test clinical support is mandatory).
Through a private healthcare provider
Step 1: Talk to your clinician
Visit a private healthcare or wellness services provider and talk to a clinician about getting the test. If they are not already an Everything Genetic sales partner, they can set up an account with us and order the test kit on your behalf.
Step 2: Pre-test clinical support
Once your clinician has ordered your test, we will commerce your clinical support with an online pre-test video sent to you via email.
Step 3: Complete documents
You will be asked to complete, sign, and return an informed consent form and family history questionnaire.
We are unable to process your sample without you having watched in full the pre-test clinical support video and completion of the consent form and questionnaire.
Step 4: Provide a saliva sample
When you open your test kit, read the instructions carefully and use the enclosed tube to provide a saliva sample.
Step 5: Send your completed kit back to us
Post the sample pack at any post box using the postage-paid packing provided.
Step 6: Reporting
Your sample will be sequenced, and your genes analysed. A report will be generated, usually within 4 weeks of receipt of your sample in the laboratory and sent to you with a post-test clinical support video and screening guide where appropriate.
- Results►Close tab
Test results include:
- Individual polygenic risk score for breast cancer based on the high-tech analysis of 2803 genetic variants associated with breast cancer;
- Your individual risk of breast cancer compared to the rest of the female population of your age;
- Your likelihood of getting breast cancer in 10 years and risk assessment compared to a woman with average genetic risk of your age.
The test results provide answers to the following questions:
- What is my genetic risk level of breast cancer?
- At what age should I start breast cancer screening?
- Should I take additional measures to prevent breast cancer?
- Clinicians►Close tab
AnteBC is a genetic test that assesses a woman’s personalised risk of developing breast cancer using a polygenic risk score. The purpose of the AnteBC test is to reduce the risk of premature mortality due to breast cancer through advanced breast cancer screening and other preventive measures.
AnteBC test uses data from 2803 genome-wide single nucleotide polymorphisms (SNPs) to evaluate individual polygenic risks of developing breast cancer. AnteBC combines the number of risk-increasing and lowering SNPs in the genome and their effects, which are summed up to form an overall estimate. Each SNP has little impact on the overall risk of breast cancer but combining the effects of individual SNPs contributes to a clinically significant assessment of the total risk. The risk model is based on peer-reviewed international research and has been evaluated and validated using anonymous population data in the Estonian Biobank and UK Biobank.
AnteBC is used to determine the carrier status of genetic variants that affect patient’s individual risk and are combined into a polygenic risk assessment and the 10-year probability of developing the disease. Individual patient risk is put into context with the population background data and estimates about the genetic risks of individuals of the same sex, age and nationality.
AnteBC test is recommended for UK women between the ages of 30 and 75.
AnteBC is a registered CE-marked medical device (IVD) developed by the Antegenes Medical Laboratory.
This test includes mandatory pre and post-test clinical support by an Everything Genetic doctor. However, if your patient would prefer that this is provided by a qualified professional within your practice, they can opt out of this service.
How to access this test for your patients
We offer this service either directly to patients or through private medical clinics and wellness service providers.
If you already have an account set up with Everything Genetic, you can order the test kit online by logging into your online account.
If you don’t have an account set up and would like to order a test kit on behalf of a patient, contact our sales team today to discuss your requirements.
- Validation►Close tab
References:
Tasa, T., Puustusmaa, M., Tonisson, N., Kolk, B., & Padrik, P. (2020). Precision Breast Cancer Screening with Polygenic Risk Score. medRxiv. View here >Mavaddat N, Michailidou K, Dennis J, Lush M, Fachal L, Lee A, et al. Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes. Am J Hum Genet. 2019;104(1):21-34. View here >
This test is provided by:
