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AnteCRC (Colorectal) logo

For technical support, please call
+44 (0) 1270 623 179 or email
info@everythinggeneticltd.co.uk
(For opening times, please click here)

Is the AnteCRC (Colorectal) test right for you?

AnteCRC is a genetic test that assesses your risk of developing colorectal cancer. This test defines personal genetic predisposition for colorectal cancer. Based on personal risk level, it is possible to give scientific and practical personalised recommendations to prevent or detect colorectal cancer at an early stage when it is still treatable.

AnteCRC test is recommended for UK women and men between the ages of 40-75.

You can access this test:

  • By purchasing it directly through Everything Genetic online (includes mandatory pre and post-test support), or
  • Through a private medical clinic or wellness services provider. Ask your clinician about how you can get this test.

This test includes mandatory pre and post-test support by your clinician or an Everything Genetic doctor.

Our price £299 (includes mandatory pre and post-test support)

How to Order

For Healthcare Providers and Employers:
Call us on +44 (0) 1270 623 179
or email info@everythinggeneticltd.co.uk

You must be 18+ to order this test

Why?Close tab

Colorectal cancer is a common malignancy of the digestive system with a poor prognosis and high morbidity and mortality rate. Your individual colorectal cancer risk can be very high, whether or not there is a family history of cancer. Knowing your personal cancer risk is the key to cancer prevention and longevity. Based on the level of personal risk, the test provides medical and practical recommendations for preventing colorectal cancer and reducing its potential effects.

When determining genetic risk, it is possible to identify women and men at increased risk for colorectal cancer so that they can receive timely examinations and a personal follow-up plan. By implementing precision prevention, it is possible to reduce the incidence and impact of cancer and achieve a longer life.

How?Close tab

How to take the test?

 

It’s a simple ‘spit test’ that you can do in your own home – we don’t need a blood sample, all we need is your saliva. You’ll receive a kit in the post with clear instructions on giving your sample together with all the paperwork you need to sign, which you then post back to us.

ProcessClose tab

Direct from this website

Step 1: Buy the AnteCRC (Colorectal) service

Click the ‘Buy now’ tab above and follow the instructions.

Step 2: Pre-test support

Once you have ordered your test, you will be contacted by an Everything Genetic doctor and given professional advice about how the test can help you (this pre-test support is mandatory). A test kit will then be sent directly to you.

Step 3: Provide a saliva sample

When you open your test kit, read the instructions carefully and use the enclosed tube to provide a saliva sample. Complete Test Request Form (A) (please sign consent for mandatory pre and post-test support), Informed Consent Form (B) and the Family History Questionnaire Form (C).

Step 4: Send your completed kit back to us

Post the sample pack at any post box using the postage-paid packing provided.

Step 5: Reporting

Your sample will be sequenced and your genes analysed. A report will be generated, usually within 4 weeks of receipt of your sample in the laboratory.

Step 6: Post-test support

An Everything Genetic doctor will contact you to discuss your results and their implications for you (this post-test support is mandatory).

Through a private healthcare provider

Step 1: Talk to your clinician

Visit a private healthcare or wellness services provider and talk to a clinician about getting the test. If they are not already an Everything Genetic sales partner, they can set up an account with us and order the test kit on your behalf.

Step 2: Pre-test support

Once your clinician has ordered your test, you will be contacted by an Everything Genetic doctor and given professional advice about how the test can help you (unless you opt-out from this service – see Form A in the kit). A test kit will then be sent directly to you.

Step 3: Provide a saliva sample

When you open your test kit, read the instructions carefully and use the enclosed tube to provide a saliva sample. Complete Test Request Form (A), Informed Consent Form (B) and the Family History Questionnaire Form (C).

Step 4: Send your completed kit back to us

Post the sample pack at any post box using the postage-paid packing provided.

Step 5: Reporting

Your sample will be sequenced and your genes analysed. A report will be generated, usually within 4 weeks of receipt of your sample in the laboratory.

Step 6: Post-test support

An Everything Genetic doctor will contact you to discuss your results and their implications for you (unless you opted out from this service – see Form A in the kit).

ResultsClose tab

Everything Genetic’s doctor (or your clinician) will be able to discuss your results and their implications for you.

Test results include:

  • Individual polygenic risk score for colorectal cancer based on the high-tech analysis of 91 genetic variants associated with colorectal cancer;
  • Your individual risk of colorectal cancer compared to the rest of the population of your age;
  • Your likelihood to get colorectal cancer in 10 years and risk assessment compared to a person with average genetic risk of your age.

The test results provide answers to the following questions:

  • What is my genetic risk level of colorectal cancer?
  • At what age and with what methods should I start colorectal cancer screening?
CliniciansClose tab

AnteCRC is a genetic test that assesses the patient’s personalised risk of developing colorectal cancer using a polygenic risk score. AnteCRC is one of the tools for the prevention and early detection of colorectal cancer. The purpose of the AnteCRC test is to reduce the risk of premature mortality due to colorectal cancer by primary and secondary prevention.

AnteCRC test uses data from 91 genome-wide single nucleotide polymorphisms (SNPs) to evaluate individual polygenic risks of developing colorectal cancer. AnteCRC combines the number of risk-increasing and lowering SNPs in the genome and their effects, which are summed up to form an overall estimate. Each SNP has little impact on the overall risk of colorectal cancer but combining the effects of individual SNPs contributes to a clinically significant assessment of the total risk. The risk model is based on peer-reviewed international research and has been evaluated and validated using anonymous population data of the UK Biobank.

AnteCRC is used to determine the carrier status of genetic variants that affect a patient’s individual risk and are combined into a polygenic risk assessment and the 10-year probability of developing the disease. Individual patient risk is put into context with the population background data and estimates about the genetic risks of individuals of the same sex, age and nationality.

AnteCRC test is recommended for UK women and men between the ages of 40-75.

AnteCRC is a registered CE-marked medical device (IVD) developed by the Antegenes Medical Laboratory.

How to access this test for your patients
We offer this service either directly to patients or through private medical clinics and wellness service providers. The pre and post-test support can be provided by your own clinic or Everything Genetic’s doctor.

If you already have an account set up with Everything Genetic, you can order the test kit online by logging into your online account.

Click here to order now

If you don’t have an account set up and would like to order a test kit on behalf of a patient, contact our sales team today to discuss your requirements.

Click here to contact us

ValidationClose tab

References:

Tasa, T., Puustusmaa, M., Tonisson, N., Kolk, B., & Padrik, P. (2020). Precision Colorectal Cancer Screening with Polygenic Risk Score. medRxiv. (https://www.medrxiv.org/content/10.1101/2020.08.19.20177931v1M)

Huyghe, Jeroen R., et al. “Discovery of common and rare genetic risk variants for colorectal cancer.” Nature genetics51.1 (2019): 76. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358437/)

This test is provided by:

Antegenes

Frequently asked questions

Do I need a clinician to get this test?
No. This test is available to purchase directly online or via your private healthcare/wellness clinic. However, all Antegenes test kits include mandatory pre and post-test support which will either be provided by your clinician or Everything Genetic's doctor.
How long does it take to get the results?
It takes approximately 4 weeks after your sample is received in the laboratory before you get your results.