ambrey-geneticsambry-geneticsbmi-healthcareBMIbrca-test-ukbrcabupacardio-dxcolordowndownloadfacebookforwardhalio-dxhca-healthcareHCAhearticon-burgericon-closeicon-githubicon-twitternanostringnuffield-healthnuffieldoncodnaoncomarkribbonskylinevideovitality coloricon-github
Color-Extended logo

Is Color-Extended test right for you?

This test not only examines your risk of cancer and heart disease, it also analyses genes that can influence how your body processes certain medications including those given for common pain, heart disease, and mental health issues such as anxiety or depression.

It is a comprehensive test which can give you a more complete understanding of your genes and health, particularly if you have a personal or family history of any of the conditions covered. Your own clinician or one of our specialists can help advise you about whether this test is appropriate for you.

You can get this test in a number of ways:

  • Buy it directly from this website as part of our BRCAtest uk service which includes mandatory pre-test counselling and post-test counselling by one of our network of UK Consultant Genetic Specialists.
  • Ask your clinician if you only want the test, and have other arrangements for the pre- and post-test counselling. You can only access the test this way with a clinical consultation.

Test only available to those aged 18 years or above.

Got a box? Enter your serial number in the box below. It is located on the reverse of the kit and consist of 14 numbers.

If you need any assistance, please call +44 (0) 1270 623 179.

Why?Close tab

For you

Knowing you have a genetic mutation enables you to make sure you have regular check-ups and screenings for conditions such as cancer or heart disease.

This test can also help your clinician understand how your body processes certain medications so that they can prescribe the most effective course of treatment for you.

For your family

Many mutations are known to be hereditary: if you have a mutation, there is a chance that your brothers and sisters – and your children will have it too.

Taking control

Discussing your results with a professional geneticist or your own doctor can help you:

  • understand your risks
  • monitor your health
  • select effective medication
  • consider your lifestyle or diet
  • protect your family
How?Close tab

What do I need to do?

It’s a simple ‘spit test’ that you can do in your own home – we don’t need a blood sample, all we need is your saliva. You’ll receive a kit in the post with clear instructions on giving your sample together with all the paperwork you need to sign, which you then post back to us.

ProcessClose tab

Direct from this website:

Step 1: Buy the Color-Extended service

Click the ‘Buy now’ tab above and follow the instructions.

Step 2: Pre-test counselling

You will be contacted by one of our Genetic Specialists and given professional advice about how the test can help you. A test kit will then be sent directly to you.

Step 3: Provide a saliva sample

When you open your test kit, read the instructions carefully and use the enclosed tube to provide a saliva sample. Complete Request Form (A), Consent Form (B) and the Health and History Form (C).

Step 4: Send your completed kit back to us

Post the sample pack at any post box free to: Freepost, BRCAtest uk

Step 5: Reporting

Your sample will be sequenced and your genes analysed. A report will be generated, usually within 3-4 weeks of receipt of your kit in the laboratory.

One of our network of UK-based Consultant Genetic Specialists will contact you to discuss your results and their implications for you.

Through your private healthcare provider:

Step 1: Check with your provider

We have special arrangements with many private healthcare providers to enable you to access this test. Click here for more information.

Step 2: Pre-test counselling

A clinician will talk you through the test, explain how it can help you and the arrangements for getting your test kit.

Step 3. Provide a saliva sample

When you open your Color-Extended test kit, read the instructions carefully and use the enclosed tube to provide a saliva sample. Complete Request Form (A), Consent Form (B) and the Health and History Form (C).

Step 4: Send your completed kit back to us

Post the sample pack at any post box free to: Freepost, BRCAtest uk

Step 5: Reporting

Your sample will be sequenced and your genes analysed. A report will be generated, usually within 3-4 weeks of receipt of your kit in the laboratory.

One of our network of UK-based Consultant Genetic Specialists will contact you to discuss your results and their implications for you.

CliniciansClose tab

Angelina Jolie’s decision to have genetic testing for the BRCA1 gene and subsequently undergo risk reducing mastectomy has greatly increased awareness of the personised health information that can now be obtained in the UK.

This test goes further than any other, analysing not only the inherited genetic mutations in genes which are significant in most common cancers, but also those relevant for hereditary heart conditions including Hereditary High Cholesterol (FH).

It then goes further still, analysing genes that can influence how the body processes certain medications including those given for common pain, heart disease, and mental health issues such as anxiety or depression.

To find out more, contact us on 01270 623 179

Cancer features

BRCA1 & BRCA2

2 genes that significantly impact breast and ovarian cancer risk. Recognized by the CDC as important for public health.

Lynch Syndrome

5 genes that impact colon and uterine cancer risk, among others. Recognized by the CDC as important for public health.

23 additional genes that give a more thorough understanding of risk for breast, ovarian, uterine, colon, prostate, stomach, melanoma, and pancreatic cancers**

Heart features

Hereditary High Cholesterol (FH)

3 genes linked to a genetic form of high cholesterol. Recognized by the CDC as important for public health.

28 additional genes associated with inherited heart conditions. Recognized by American College of Medical Genetics and Genomics as having actionable treatment plans.**

Medication features

2 genes that can influence how your body processes certain medications for mental health conditions

12 additional genes that can influence how your body processes common pain, heart, and other medications

** Risk information and screening guidelines in results are typically based on studies of individuals with a family history of the disorder being discussed. Medical management should be considered also taking into account on patients’ personal and family history.

 

High-quality results

Provided by our partner Color, the Color Extended test has been validated according to ACMG, AMP, and regulatory agencies’ recommendations for molecular clinical tests.

Their advanced, CAP-accredited and CLIA-certified laboratory uses the newest technology, including 2D barcoded tubes and advanced liquid-handling robots, to ensure the integrity of every result.

The quality of every sample is checked multiple times as it moves through the sequencing and interpretation process and Color’s Ph.D. and M.D. scientists use state-of-the-art tools to classify variants according to ACMG guidelines. A certified medical professional reviews every result before it is released.

Please refer to our validation papers for more details.

ValidationClose tab

References for our Color Extended Test

  1. Tung N, Battelli C, Allen B, et al. Frequency of mutations in individuals with breast cancer referred for BRCA1 and BRCA2 testing using next-generation sequencing with a 25-gene panel. Cancer. January 2015;121(1):25-33. Pubmed Abstract
  2. Pal T, Permuth-Wey J, Betts JA, et al. BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases. Cancer. December 2005;104(12):2807-16. Pubmed Abstract
  3. Risch HA, McLaughlin JR, Cole DE, et al. Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. Am J Hum Genet. March 2001;68(3):700-10. Pubmed Abstract
  4. Claus EB, Risch N, Thompson WD, et al. The calculation of breast cancer risk for women with a first degree family history of ovarian cancer. Breast Cancer Res Treat. November 1993;28(2):115-20. Pubmed Abstract
  5. King MC, Marks JH, Mandell JB. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science. 2003;302(5645):643-6. Pubmed Abstract
  6. Jasperson KW, Tuohy TM, Neklason DW, Burt RW. Hereditary and familial colon cancer. Gastro. 2010 Jun;138(6):2044-58.
  7. Burt RW, et al. Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis. Gastro. 2004 Aug;127(2):444-51.
  8. SEER Stat Fact Sheets: Breast Cancer. Published November 2013. National Cancer Institute
  9. Moyer VA on behalf of the U.S. Preventive Services Task Force. Risk assessment, genetic counselling, and genetic testing for BRCA-related cancer in women: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2014 Feb 18;160(4):271-81.

This test is provided by:

BRCAtest UK

Color

Frequently asked questions

Do I need a doctor to authorise this test?
No, you can buy it directly from this website – our service includes counselling to confirm if the test will be helpful to you and to help you understand the results.
Will my health insurance cover the cost of this test?
Many health insurance plans cover the cost of genetic testing – check with your provider to find out if it is in your policy
How soon do I get my results?
Usually within 3-4 weeks of receipt of your kit in the laboratory
How accurate is the test?
Color’s laboratory has been accredited by the College of American Pathologists (CAP) and has Clinical Laboratory Improvement Amendments (CLIA) certification. The Color Test showed >99% accuracy in multiple validation studies.