Is the AnteMEL (Melanoma) test right for you?
AnteMEL is a genetic test that assesses your risk of developing skin melanoma. This test defines personal genetic predisposition for melanoma. Based on personal risk level, it is possible to give scientific and practical personalised recommendations for melanoma risk management and screening.
AnteMEL test is recommended for UK women and men between the ages of 18-70.
This test is only suitable for individuals who have no previous history of melanoma.
You can access this test:
- By purchasing it directly through Everything Genetic online (includes mandatory pre and post-test clinical support), or
- Through a private medical clinic or wellness services provider. Ask your clinician about how you can get this test.
This test includes mandatory pre and post-test clinical support from Everything Genetic.
Our price £249 (includes mandatory pre and post-test clinical support)
For Healthcare Providers and Employers:
Call us on +44 (0) 1270 623179 or email
partners@everythinggeneticltd.co.uk
You must be 18+ to order this test
- Why?►Close tab
Melanoma is the most aggressive form of skin cancer. Your individual melanoma risk can be very high, whether or not there is a family history of cancer. Knowing your personal cancer risk is the key to cancer prevention and longevity. Based on the level of personal risk, the test provides medical and practical recommendations for preventing melanoma and reducing its potential effects.
When determining genetic risk, it is possible to identify women and men at increased risk for melanoma so that they can receive timely examinations and a personal follow-up plan. By implementing precision prevention, it is possible to reduce the incidence and impact of cancer and achieve a longer life.
- How?►Close tab
How to take the test?
It’s a simple ‘spit test’ that you can do in your own home – we don’t need a blood sample, all we need is your saliva. You’ll receive a kit in the post with clear instructions on giving your sample together with all the paperwork you need to sign, which you then post back to us.
- Process►Close tab
Direct from this website
Step 1: Buy the AnteMEL (Melanoma) service
Click the ‘Buy now’ tab above and follow the instructions.
Step 2: Pre-test clinical support
Once you have ordered your test, you will be contacted by an Everything Genetic doctor and provided with clinical support on how the test works (this pre-test clinical support is mandatory). A test kit will then be sent directly to you.
Step 3: Provide a saliva sample
When you open your test kit, read the instructions carefully and use the enclosed tube to provide a saliva sample. Complete Test Request Form (A) (please sign consent for mandatory pre and post-test clinical support), Informed Consent Form (B) and the Family History Questionnaire Form (C).
Step 4: Send your completed kit back to us
Post the sample pack at any post box using the postage-paid packing provided.
Step 5: Reporting
Your sample will be sequenced and your genes analysed. A report will be generated, usually within 4 weeks of receipt of your sample in the laboratory.
Step 6: Post-test clinical support
An Everything Genetic doctor will contact you to discuss your results and their implications for you (this post-test clinical support is mandatory).
Through a private healthcare provider
Step 1: Talk to your clinician
Visit a private healthcare or wellness services provider and talk to a clinician about getting the test. If they are not already an Everything Genetic sales partner, they can set up an account with us and order the test kit on your behalf.
Step 2: Pre-test clinical support
Once your clinician has ordered your test, we will commerce your clinical support with an online pre-test video sent to you via email.
Step 3: Complete documents
You will be asked to complete, sign, and return an informed consent form and family history questionnaire.
We are unable to process your sample without you having watched in full the pre-test clinical support video and completion of the consent form and questionnaire.
Step 4: Provide a saliva sample
When you open your test kit, read the instructions carefully and use the enclosed tube to provide a saliva sample.
Step 5: Send your completed kit back to us
Post the sample pack at any post box using the postage-paid packing provided.
Step 6: Reporting
Your sample will be sequenced, and your genes analysed. A report will be generated, usually within 4 weeks of receipt of your sample in the laboratory and sent to you with a post-test clinical support video and screening guide where appropriate.
- Results►Close tab
Test results include:
- Individual polygenic risk score for melanoma based on the high-tech analysis of 28 genetic variants associated with melanoma;
- The individual risk of melanoma compared to the rest of the population of your age;
- Likelihood to get melanoma in 10 years and risk assessment compared to a person with average genetic risk of your age.
The test results provide answers to the following questions:
- What is my genetic risk level for melanoma?
- How often should I see a doctor to check my skin for melanoma?
- Clinicians►Close tab
AnteMEL is a genetic test that assesses the patient’s personalised risk of developing melanoma using a polygenic risk score. AnteMEL is one of the tools for the prevention and early detection of melanoma. The purpose of the AnteMEL test is to reduce the risk of premature mortality due to melanoma by primary and secondary prevention.
AnteMEL test uses data from 28 genome-wide single nucleotide polymorphisms (SNPs) to evaluate individual polygenic risks of developing melanoma. AnteMEL combines the number of risk-increasing and lowering SNPs in the genome and their effects, which are summed up to form an overall estimate. Each SNP has little impact on the overall risk of melanoma but combining the effects of individual SNPs contributes to a clinically significant assessment of the total risk. The risk model is based on peer-reviewed international research and has been evaluated and validated using anonymous population data of the UK Biobank.
AnteMEL is used to determine the carrier status of genetic variants that affect a patient’s individual risk and are combined into a polygenic risk assessment and the 10-year probability of developing the disease. Individual patient risk is put into context with the population background data and estimates about the genetic risks of individuals of the same sex, age and nationality.
AnteMEL test is recommended for UK women and men between the ages of 18 and 70.
AnteMEL is a registered CE-marked medical device (IVD) developed by the Antegenes Medical Laboratory.
This test includes mandatory pre and post-test support by an Everything Genetic doctor. However, if your patient would prefer that this consultation is provided by a qualified professional within your practice, they can opt-out from this service.
How to access this test for your patients
We offer this service either directly to patients or through private medical clinics and wellness service providers.If you already have an account set-up with Everything Genetic, you can order the test kit online by logging into your online account.
If you don’t have an account set-up and would like to order a test kit on behalf of a patient, contact our sales team today to discuss your requirements.
- Validation►Close tab
References:
Tasa, T., Puustusmaa, M., Tonisson, N., Kolk, B., & Padrik, P. (2020). Recommendations for Primary Prevention of Skin Melanoma. medRxiv. View here>
Fritsche LG, Beesley LJ, VandeHaar P, Peng RB, Salvatore M, Zawistowski M, et al. Exploring various polygenic risk scores for skin cancer in the phenomes of the Michigan genomics initiative and the UK Biobank with a visual catalog: PRSWeb. PLoS Genet. 2019;15(6):e1008202. View here >
This test is provided by:
